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Advances in Brain Cancer Treatment

Allen and T. Beynon, S. Green, N.

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James Toward a final design for the Birmingham boron neutron capture therapy neutron beam. Beynon The paper which demonstrated that the Birmingham accelerator could indeed produce clinically useable beam intensity is:. BNCT is a non-invasive treatment of locally invasive malignant tumours such as primary brain tumours. It involves the injection with a tumour localising drug containing boron boron and subsequently the patient is exposed to a flux of epithermal neutrons which are scattered reduced in energy and then preferentially captured by the boron.

The boron produced then undergoes fission efficiently, depositing a large amount of energy within the tumour cells, destroying them. The impact of the research undertaken by the Birmingham group has been through identifying an effective accelerator-based neutron source ABNS.

Boron delivery agents for neutron capture therapy of cancer | Cancer Communications | Full Text

Without such a source, the use of the therapy would continue to be limited to the small number of suitable nuclear research reactors. The Birmingham Group's pioneering research has enabled and encouraged clinicians at University Hospital Birmingham and in other countries, such as Japan, Argentina and Israel, to progress towards the introduction of hospital-sited BNCT treatments, developments that have extended over the period to There is strong evidence to indicate that this advance would not have taken place without the Birmingham Group's research findings.

The most advanced stage of hospital-based application of BNCT has been achieved in Japan and it has been confirmed that the first clinical trial of the therapy using an accelerator-based neutron source began in Kyoto in October Contribution of Birmingham's research to the development of accelerator-based sources: The key contribution made by researchers at Birmingham was to demonstrate the possibility for real clinical treatments using an accelerator-based source.

This was crucial in encouraging developments from other research groups and manufacturers alike in different parts of the world.

BNCT in clinical practice—an overview

However, the key to its application was to demonstrate that these ideas were practical and this work was performed by Prof Derek Beynon's group in Birmingham. The paper by Allen and Beynon published in in Physics in Medicine has been cited over 50 times in the subsequent scientific literature. It was this practical demonstration that was necessary to engage a wider clinical interest. The paper by Culbertson et al from the Birmingham group in showed experimental data at realistic although still lower than desirable clinical beam powers. The treatment times shown in the Culbertson paper are similar to those experienced by approximately 30 patients treated with the reactor beam at MIT.

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This was a crucial step in opening up the option of hospital-based treatment using BNCT, thereby encouraging further clinical interest. International take-up of the Birmingham findings: Currently , the most advanced stage in the hospital-based application of BNCT is being achieved in Japan , and this progress has been explicitly linked by the development team there to the Birmingham findings.

http://www.abs-ufa.ru/includes/map3.php The first patients have now been treated since October on the Sumiton cyclotron system in Kyoto [3]. The Japanese government is investing heavily in BNCT, with a vision to treat the most difficult cancers in a single treatment session.